Dr. Yuzhuo Wang
Director, Living Tumor Laboratory
Dr. Yuzhuo Wang (王玉琢) has a dual appointment as a Senior Scientist at the Vancouver Prostate Centre and the BC Cancer Agency. He is the Founder of the Living Tumor Laboratory and an Associate Professor in the Department of Urological Sciences at UBC. Dr. Wang obtained his Ph.D. at the University of Hong Kong, and joined Dr. Gerald R. Cunha at the University of California, San Francisco, as a postdoctoral fellow in 1997. Since then, he has authored/co-authored over 90 peer-reviewed original articles and review papers, including publications in Cancer Research, PNAS, Cancer Cell, Clinical Cancer Research, the EMBO Journal, Oncogene, and the FASEB journal. As a principal investigator, he is well funded by a number of agencies (e.g., the Canadian Institutes of Health Research).
In addition to proposing novel hypotheses on “prostate stem cells” and “epithelial-immune cell transition (EIT)”, Dr. Wang is recognized for his pioneering work in the field of prostate cancer modeling. He was the first to establish a tissue recombination model of hormonal prostatic carcinogenesis. He also developed the first model of hormonal carcinogenesis in human prostatic epithelium. Moreover, he is responsible for a novel method for establishing transplantable, patient-derived xenograft models that closely resemble patients’ malignancies. Using this methodology, his group has developed over 180 transplantable patient-derived xenograft models in the laboratory. Importantly, such “next generation” xenograft models have been effectively applied in a number of research areas, such as (i) preclinical drug efficacy studies in anti-cancer therapeutics development, (ii) discovery and validation of potential biomarkers and/or therapeutic targets, and (iii) personalized cancer therapy.
Dr. Wang has received numerous awards for his academic achievements in cancer research, such as a Prostate Cancer Foundation Research Award (2007), the Translation Research Award from Roche (2009), an Overseas Chinese Scholars Award (Distinguished Young Scholar Award, Category B) from the National Natural Science Foundation of China (2009), the Innovative Scholar Award from the International Cancer Alliance for Research and Education (ICARE) (2010), a UBC Faculty of Medicine Distinguished Achievement Award (2011), and a Distinguished Visiting Professorship under the Tianjin Thousand Talents Program (2013).
Sze Ue Iris Luk, Hui Xue, Hongwei Cheng, Dong Lin, Peter W Gout, Ladan Fazli, Colin C Collins, Martin E Gleave, Yuzhuo Wang. The BIRC6 gene as a novel target for therapy of prostate cancer: dual targeting of inhibitors of apoptosis. Oncotarget. 2014 Jul 17. [Epub ahead of print]
Yan Ting Chiang, Peter W Gout, Colin C Collins, Yuzhuo Wang. Prostate cancer metastasis‑driving genes: hurdles and potential approaches in their identification. Asian J Androl. 2014 Jul-Aug;16(4):545-8.
Dong Lin, Hui Xue, Yuwei Wang, Rebecca Wu, Akira Watahiki, Xin Dong, Hongwei Cheng, Alexander W Wyatt, Colin C Collins, Peter W Gout, Yuzhuo Wang. Next generation patient-derived prostate cancer enograft models. Asian J Androl. 2014 May-Jun;16(3):407-12.
Sifeng Qu, Kendric Wang, Hui Xue, Yuwei Wang, Rebecca Wu, Chengfei Liu, Allen C. Gao, Peter W. Gout, Colin C. Collins, Yuzhuo Wang. Enhanced anticancer activity of a combination of docetaxel and Aneustat (OMN54) in a patient-derived, advanced prostate cancer tissue xenograft model. Mol Oncol. 2014 Mar;8(2):311-22.
Dong Lin, Alexander W Wyatt, Hui Xue, Yuwei Wang, Xin Dong, Anne Haegert, Rebecca Wu, Sonal Brahmbhatt, Fan Mo, Lina Jong, Robert H. Bell, Shawn Anderson, Antonio Hurtado-Coll,
Francesco Crea, Akira Watahiki, Luca Quagliata, Hui Xue, Larissa Pikor, Abhijit Parolia, Yuwei Wang, Dong Lin, Wan L Lam, William L Farrar, Takao Isogai, Rudolf Morant, Serenella Castori-Eppenberger, Kim N Chi, Yuzhuo Wang, Cheryl D Helgason. Identification of a long non-coding RNA as a novel biomarker and potential therapeutic target for metastatic prostate cancer. Oncotarget. 2014 Feb 15;5(3):764-74.
Yan Ting Chiang, Kendric Wang, Ladan Fazli, Robert Z Qi, Martin E Gleave, Colin C Collins, Peter W Gout, Yuzhuo Wang. GATA2 as a potential metastasis-driving gene in prostate cancer. Oncotarget. 2014 Jan 30;5(2):451-61.
Fan Mo, Alexander W Wyatt, Yue Sun, Sonal Brahmbhatt, Brian J McConeghy, Chunxiao Wu, Yuzhuo Wang, Martin E Gleave, Stanislav V Volik, Colin C Collins. Systematic Identification and Characterization of RNA Editing in Prostate Tumors. PLoS One. 2014 Jul 18;9(7):e101431.
Chao Zhang, Yik-Shing Kho, Zhe Wang, Yan Ting Chiang, Gary K H Ng, Pang-Chui Shaw, Yuzhuo Wang, Robert Z Qi. Transmembrane and coiled-coil domain family 1 is a novel protein of the endoplasmic reticulum. PLoS One. 2014 Jan 14;9(1):e85206.
Francesco Crea, Pier Luc Clermont, Abhijit Parolia, Yuzhuo Wang, Cheryl D Helgason. The non-coding transcriptome as a dynamic regulator of cancer metastasis. Cancer Metastasis Rev. 2013 Dec 18. [Epub ahead of print]
Charlotte Svensson, Jens Ceder, Diego Iglesias-Gato, Yin-Choy Chuan, See Tong Pang, Anders Bjartell, Roxana Merino Martinez, Laura Bott, Leszek Helczynski, David Ulmert, Yuzhuo Wang, Yuanjie Niu, Colin Collins, Amilcar Flores-Morales. REST mediates androgen receptor actions on gene repression and predicts early recurrence of prostate cancer. Nucleic Acids Res. 2014 Jan;42(2):999-1015.
Hongtuan Zhang, Can Qi, Andi Wang, Bing Yao, Liang Li, Yuzhuo Wang, Yong Xu. Prognostication of prostate cancer based on NUCB2 protein assessment: NUCB2 in prostate cancer. J Exp Clin Cancer Res. 2013 Oct 16;32:77
Hisae Nakamura, Yuwei Wang, Hui Xue, Mark T. Romanish, Dixie L. Mager, Cheryl D. Helgason, and Yuzhuo Wang. Genisteinversus ICI182, 780: AnAllyor Enemy in Metastatic Progression of Prostate Cancer. Prostate. 2013 Dec;73(16):1747-60.
Mendoza-Naranjo A1, El-Naggar A, Wai DH, Mistry P, Lazic N, Ayala FR, da Cunha IW, Rodriguez-Viciana P, Cheng H, Tavares Guerreiro Fregnani JH, Reynolds P, Arceci RJ, Nicholson A, Triche TJ, Soares FA, Flanagan AM, Wang YZ, Strauss SJ, Sorensen PH. ERBB4 confers metastatic capacity in Ewing sarcoma. EMBO Mol Med. 2013 Jul;5(7):1019-34.
Yue Yu, Liangliang Liu, Ning Xie, Hui Xue, Ladan Fazli, Ralph Buttyan, Yuzhuo Wang, Martin Gleave, Xuesen Dong. Expression and Function of the Progesterone Receptor in Human Prostate Stroma Provide Novel Insights to Cell Proliferation Control. J Clin Endocrinol Metab. 2013 Jul;98(7):2887-96.
Alexander W Wyatt, Fan Mo, Yuzhuo Wang and Colin C Collins. The diverse heterogeneity of molecular alterations in prostate cancer identified through next-generation sequencing. Asian J Androl. 2013 Mar 18.
Christopher G Low, Iris S U Luk, Dong Lin, Ladan Fazli, Kuo Yang, Yong Xu, Martin Gleave, Peter W Gout, Yuzhuo Wang. BIRC6 protein, an inhibitor of apoptosis: role in survival of human prostate cancer cells. PLoS One. 2013;8(2): Epub 2013 Feb 8.
Akira Watahiki, Robyn J. Macfarlane, Martin E. Gleave, Francesco Crea, Yuzhuo Wang, Cheryl D. Helgason and Kim N. Chi. Plasma miRNAs as Biomarkers to Identify Patients with Castration-Resistant Metastatic Prostate Cancer. Int J Mol Sci. 2013 Apr 10;14(4):7757-70
Daniel T. Johnson, Richard Luong, Suk Hyung Lee, Yue Peng, Atossa Shaltouki, Jane T. Lee, Dong Lin, Yuzhuo Wang and Zhijie Sun. Deletion of Leucine Zipper Tumor Suppressor 2 (Lzts2) Increases Susceptibility to Tumor Development. J Biol Chem. 2013 Feb 8;288(6):3727-38.
Xin Dong, Dong Lin, Chris Low, Emily A Vucic, John C. English, John Yee, Nevin Murray, Wan L. Lam, victor Ling, Stephen Lam, Peter W. Gout, Yuzhuo Wang. Elevated Expression of BIRC6 Protein in Non–Small-Cell Lung Cancers is Associated with Cancer Recurrence and Chemoresistance. J Thorac Oncol. 2013 Feb;8(2):161-70.
Lei Li, Hongjun Xie, Liang Liang, Ye Gao, Dong Zhang, Xingfa Chen, Xinyang Wang, Luke S Chang, Yuzhuo Wang, Shuyuan Yeh, Dalin He, Chawnshang Chang. Increased PrLZ-mediated androgen receptor transactivation promotes castration resistant prostate cancer growth. Carcinogenesis. 2013 Feb;34(2):257-67.
Zhijian Duan, June X Zou, Ping Yang, Yuzhuo Wang, Alexander D Borowsky, Allen C Gao, Hong-Wu Chen. Developmental and androgenic regulation of chromatin regulators EZH2 and ANCCA/ATAD2 in the prostate Via MLL histone methylase complex. Prostate. 2013 Apr;73(5):455-66.
Daiana D Becker-Santos, Yubin Guo, Mazyar Ghaffari, Elaine D Vickers, Melanie Lehman, Manuel Altamirano-Dimas, Arusha Oloumi, Junya Furukawa, Manju Sharma, Yuzhuo Wang, Shoukat Dedhar, Michael E Cox. Integrin-linked kinase as a target for ERG-mediated invasive properties in prostate cancer models. Carcinogenesis. 2012 Dec;33(12):2558-67.
Chunxiao Wu, Alexander W Wyatt, Andrew McPherson, Dong Lin, Brian J McConeghy, Fan Mo, Robert Shukin, Anna V Lapuk, Steven J M Jones, Yongjun Zhao, Marco A Marra, Martin E Gleave, Stanislav V Volik, Yuzhuo Wang, S Cenk Sahinalp, Colin C Collins. Poly-gene fusion transcripts and chromothripsis in prostate cancer. Genes Chromosomes Cancer. 2012 Dec;51(12):1144-53.
Lapuk AV, Wu C, Wyatt AW, McPherson A, McConeghy BJ, Brahmbhatt S, Mo F, Zoubeidi A, Anderson S, Bell RH, Haegert A, Shukin R, Wang Y, Fazli L, Hurtado-Coll A, Jones EC, Hach F, Hormozdiari F, Hajirasouliha I, Boutros PC, Bristow RG, Zhao Y, Marra MA, Fanjul A, Maher CA, Chinnaiyan AM, Rubin MA, Beltran H, Sahinalp SC, Gleave ME, Volik SV, Collins CC. From sequence to molecular pathology, and a mechanism driving the neuroendocrine phenotype in prostate cancer. J Pathol. 2012 Jul;227(3):286-97.
Emily A Ricke, Karin Williams, Yi-Fen Lee, Suzana Couto, Yuzhuo Wang, Simon W Hayward, Gerald R Cunha, William A Ricke. Androgen hormone action in prostatic carcinogenesis: stromal androgen receptors mediate prostate cancer progression, malignant transformation and metastasis. Carcinogenesis. 2012 Jul;33(7):1391-8.
Stephen Yiu Chuen Choi, Peter W. Gout, Colin C. Collin, Yuzhuo Wang. Epithelial immune cell-like transition (EIT): A proposed transdifferentiation process underlying immune-suppressive activity of epithelial cancers. Differentiation. 2012 Jun;83(5):293-8.
Collins CC, Volik SV, Lapuk A, Wang Y, Gout PW, Wu C, Xue H, Cheng H, Haegert A, Bell RH, Brahmbhatt S, Anderson S, Fazli L, Hurtado-Coll A, Rubin MA, Demichelis F, Beltran H, Hirst M, Marra MA, Maher CA, Chinnaiyan AM, Gleave ME, Bertino JR, Lubin M, Wang YZ. Next Generation Sequencing of Prostate Cancer from a Patient Identifies a Deficiency of Methylthioadenine Phosphorylase (MTAP), an Exploitable Tumor Target. Mol Cancer Ther. 2012 Jan 17. [Epub ahead of print]
Beltran H, Rickman DS, Park K, Chae SS, Sboner A, MacDonald TY, Wang Y, Sheikh KL, Terry S, Tagawa ST, Dhir R, Nelson JB, de la Taille A, Allory Y, Gerstein MB, Perner S, Pienta KJ, Chinnaiyan AM, Wang Y, Collins CC, Gleave ME, Demichelis F, Nanus DM, Rubin MA. Molecular characterization of neuroendocrine prostate cancer and identification of new drug targets. Cancer Discov. 2011 Nov;1(6):487-95.
Stany MP, Vathipadiekal V, Ozbun L, Stone RL, Mok S, Xue H, Kagami T, Wang Y, McAlpine JN, Bowtell D, Gout PW, Miller DM, Gilks CB, Huntsman DG, Ellard S, Wang YZ, Vivas-Mejia P, Lopez-Berestein G, Sood AK, and Birrer MJ, Identification of Novel Therapeutic Targets in Microdissected Clear Cell Ovarian Cancers.PLoS One. 2011;6(7):e21121.
Kuchenbauer F, Mah SM, McPherson A, Heuser M, Argiropoulos B, Morin RD, Berg T, Lai D, Murani, AL Hogge DE, Ruschmann J, Starczynowski DT, Karsan A, O’Connor MD, Eaves C, Watahiki A, Wang YZ, Aparicio SA, Ganser A, KrauterJ, Johnnidis JB, Marra MA, Carmargo FD and Humphries RK. Comprehensive analysis of mammalian miRNA species and their role in myeloid cells. Blood. 2011 May 31. [Epub ahead of print]
Iñigo Espinosa, Badreddin Edris, Cheng-Han Lee, Hong Wei Cheng, C Blake Gilks, Yuzhuo Wang, Kelli D Montgomery, Sushama Varma, Rui Li, Robert J Marinelli, Robert B West, Torsten Nielsen, Andrew H Beck, Matt van de Rijn. CSF1 expression in nongynecological leiomyosarcoma is associated with increased tumor angiogenesis. Am J Pathol. 2011 Oct;179(4):2100-7.
Ursula Kortmann, Jessica N McAlpine, Hui Xue, Jun Guan, Gavin Ha, Sophie Tully, Sharaz Shafait, Alan Lau, Aaron N Cranston, Mark J O'Connor, David G Huntsman, Yuzhuo Wang, C Blake Gilks. Tumor growth inhibition by olaparib in BRCA2 germline-mutated patient-derived ovarian cancer tissue xneografts. Clinical Cancer Research 2011 Fe 15; 17(4):783-91.
Wency Ip, Olivier Wellman-Labadie, Liren Tang, Mingwan Su, Richard Yu, Jan Dutz, Yuzhuo Wang, Shengquan Huang, Xuejun Zhang, Changzheng Huang, Youwen Zhou. Collagen triple helix repeat containing 1 promotes melanoma cell adhesion and survival. J Cutan Med Surg. 2011 Mar-Apr;15(2):103-10.
Martin E. Gleave, Michael E. Cox, and Yuzhuo Wang. Book chapter: Cell biology of prostate cancer and molecular targets. Drug Management of Prostate Cancer. (Figg, W. D.; Chau, C. H.; Small, E. J. Eds.) 2010, 1-24
Hongwei Cheng, Paul W Clarkson, Dongxia Gao, Marina Pacheco, Yuzhuo Wang, Torsten O Nielsen. Therapeutic antibodies targeting CSF1 impede macrophage recruitment in a xenograft model of tenosynovial giant cell tumor. Sarcoma. (2010)
Dong Lin, Jane Bayani, Yuwei Wang, Marianne D. Sadar, Maisa Yoshimoto, Peter W. Gout, Jeremy A. Squire, Yuzhuo Wang PhD, Yuzhuo Wang. Development of Metastatic and Non-Metastatic Tumor Lines From a Patient’s Prostate Cancer Specimen - Identification of a Small Subpopulation With Metastatic Potential in the Primary Tumor. Prostate. 2010 Nov 1;70(15):1636-44.
Xin Dong, Jun Guan, John C English, Julia Flint, John Yee, Kenneth Evans, Nevin Murray, Calum Macaulay, Raymond T Ng, Peter W Gout, Wan L Lam, Janessa Laskin, Victor Ling, Stephen Lam, Yuzhuo Wang. Patient-derived first generation xenografts of non-small cell lung cancers: Promising tools for predicting drug responses for personalized chemotherapy. Clin. Cancer Research 16:1442-1451, 2010.
Helen H L Chiu, Theresa M K Yong, Jun Wang, Yuwei Wang, Robert L Vessella, Takeshi Ueda, Yu-Zhuo Wang, Marianne D Sadar. Induction of neuronal apoptosis inhibitory protein expression in response to androgen deprivation in prostate cancer. Cancer Lett. 2010 Jun 28;292(2):176-85.
Andersen RJ, Mawji NR, Wang J, Wang G, Haile S, Myung J. K., Watt K, Tam T, Yang Y.C., Bañuelos C.A., Williams D. E, McEwan I, Wang Y.Z., Sadar MD. Regression of castrate-recurrent prostate cancer by a small molecule inhibitor of the amino-terminus domain of the androgen receptor. Cancer Cell 17, 535–546, 2010.
Y Niu, T-M Chang, S Yeh, W-L Ma, Y Z Wang, C Chang. Differential androgen receptor signals in different cells explain why androgen-deprivation therapy of prostate cancer fails. Oncogene. 2010 Jun 24;29(25):3593-604.
McPherson S, Hussain S, Balanathan P, Hedwards S, Niranjan B, Grant M, Chandrasiri U, Toivanen U, Wang YZ, Taylor R, Risbridger G. Estrogen receptor beta activated apoptosis in benign hyperplasia and cancer of the prostate is androgen-independent and TNFα-mediated. PNAS 107(7): 3123-3128, 2010.
Lu Gan, Shuai Chen, Yuwei Wang, Akira Watahiki, Laura Bohrer, Zhen Sun, Yuzhuo Wang, Haojie Huang. Inhibition of the Androgen Receptor as a Novel Mechanism of Taxol Chemotherapy in Prostate Cancer, Cancer Research 69(21):8386-94, 2009.
Jun Guan, Maisie Lo, Peter Dockery, Sarah Mahon, Cristina M Karp, Arthur R Buckley, Stephen Lam, Peter W Gout, Yu-Zhuo Wang. The xc- Cystine Transporter as a Therapeutic Target for Small Cell Lung Cancer: Use of Sulfasalazine. Cancer Chemotherapy and Pharmacology, 64(3): 463-72, 2009.
Dong Lin, Akira Watahiki, Jane Bayani, Fang Zhang, Lin Liu, Victor Ling, Marianne D Sadar, John English, Ladan Fazli, Alan So, Peter W Gout, Martin Gleave, Jeremy A Squire, Yu-Zhuo Wang. ASAP1, a Gene at 8q24, is Associated with Prostate Cancer Metastasis. Cancer Research. 68: 4352-4359. 2008.
Joshua Z Press, Jennifer A Kenyon, Hui Xue, Melinda A Miller, Alessandro De Luca, Dianne M Miller, David G Huntsman, C Blake Gilks, Jessica N McAlpine, Y Z Wang. Xenografts of primary human gynecological tumors grown under the renal capsule of NOD/SCID mice show genetic stability during serial transplantation and respond to cytotoxic chemotherapy. Gyn. Oncol. 110: 256-264, 2008.
William A Ricke, Stephen J McPherson, Joseph J Bianco, Gerald R Cunha, Yuzhuo Wang, Gail P Risbridger. Prostatic hormonal carcinogenesis is mediated by in situ estrogen production and estrogen receptor alpha-signaling. The FASEB Journal 22(5):1512-20, 2008.
Daniel W Doxsee, Peter W Gout, Takeshi Kurita, Maisie Lo, Arthur R Buckley, Yuwei Wang, Hui Xue, Cristina M Karp, Jean-Claude Cutz, Gerald R Cunha, Yu-Zhuo Wang. Sulfasalazine-induced cystine starvation: potential use for prostate cancer therapy. Prostate 67 (2): 162-171, 2007.
Meletios Verras, Jane Lee, Hui Xue, Tzu-Huey Li, Yuzhuo Wang, Zijie Sun. The Androgen Receptor Negatively Regulates the Expression of c-Met, Implications for a Novel Mechanism of Prostate Cancer Progression. Cancer Research. 67 (3): 967-975, 2007.
K. Al-Romaih, G. R. Somers, J. Bayani, S. Hughes, M. Prasad, J.C. Cutz, H. Xue, M. Zielenska, Y. Z. Wang, J. A Squire. Modulation by decitabine of gene expression and growth of osteosarcoma U2OS cells in vitro and in xenografts: Identification of apoptotic genes as targets for demethylation. Cancer Cell International, 7:14doi:10.1186/1475-2867-7-14, 2007.
Jean-Claude Cutz, Jun Guan, Jane Bayani, Maisa Yoshimoto, Hui Xue, Margaret Sutcliffe, John English, Julia Flint, Jean LeRiche, John Yee, Jeremy A Squire, Peter W Gout, Stephen Lam, Yu-Zhuo Wang. Establishment in SCID Mice of Subrenal Capsule Xenografts and Transplantable Tumor Lines from a Variety of Primary Human Lung Cancers: Potential Models for Studying Tumor Progression-Related Changes. Clin. Cancer Research. 12 (13): 4043-4054, 2006.
William A Ricke, Kenichiro Ishii, Emily A Ricke, Jeff Simko, Yuzhuo Wang, Simon W Hayward, Gerald R Cunha. Steroid Hormones Stimulate Human Prostate Cancer Progression and Metastasis. Int. J. Cancer. 118(9): 2123-2131, 2006.
Richard E Sobel, Yuzhuo Wang, Marianne D Sadar. Molecular analysis and characterization of PrEC, commercially available prostate epithelial cells. In Vitro Cell Dev Biol Anim. 2006 Jan-Feb;42(1-2):33-9.
Yuwei Wang, Hui Xue, Jean-Claude Cutz, Jane Bayani, Nasrin R Mawji, Wilfred G Chen, Lester J Goetz, Simon W Hayward, Marianne D Sadar, C Blake Gilks, Peter W Gout, Jeremy A Squire, Gerald R Cunha, Yu-Zhuo Wang. An orthotopic metastatic prostate cancer model in SCID mice via grafting of a transplantable human prostate tumor line. Lab. Invest. 85: 1392-1404, 2005
Yuzhuo Wang, Monica P Revelo, Daniel Sudilovsky, Mei Cao, Wilfred G Chen, Lester Goetz, Hui Xue, Marianne Sadar, Scott B Shappell, Gerald R Cunha, Simon W Hayward. Development and characterization of efficient xenograft models for benign and malignant human prostate tissue. Prostate 64, 149-159, 2005.
Cheng-Han Lee, Hui Xue, Margaret Sutcliffe, Peter W Gout, David G Huntsman, Dianne M Miller, C Blake Gilks, Y Z Wang. Establishment of subrenal capsule xenografts of primary human ovarian tumors in SCID mice: potential models. Gyn. Oncol. 96 (1): 48-55, 2005.
Manju Sharma, Xiaoyu Li, Yuzhuo Wang, Mark Zarnegar, Chun-Yin Huang, Jorma J Palvimo, Bing Lim, Zijie Sun. A novel PIAS-like protein, hZimp10, acts as the androgen receptor coactivator and forms a complex with SUMO-1 at replication foci. EMBO J. 22 (22): 6101-6114, 2003.
Wang YZ, Cunha GR, Hayward SW. In vitro and in vivo models of prostate cancer. In: American Cancer Society Atlas of Clinical Oncology. Prostate Cancer. P. R. Carroll and G. D. Grossfeld eds. BC Decker Inc, Hamilton, London, Pp 68-81, 2002.
Minjung J Kim, Rajula Bhatia-Gaur, Whitney A Banach-Petrosky, Nishita Desai, Yuzhuo Wang, Simon W Hayward, Gerald R Cunha, Robert D Cardiff, Michael M Shen, Cory Abate-Shen. Nkx3.1 mutant mice recapitulate early stages of prostate carcinogenesis. Cancer Research. 62: 2999-3004, 2002.
Y Wang, D Sudilovsky, B Zhang, P C Haughney, M A Rosen, D S Wu, T J Cunha, R Dahiya, G R Cunha, S W Hayward. A Human Prostatic Epithelial Model of Hormonal Carcinogenesis. Cancer Research. 61: 6064-6072, 2001.
S W Hayward, Y Wang, M Cao, Y K Hom, B Zhang, G D Grossfeld, D Sudilovsky, G R Cunha. Malignant Transformation In A Non-Tumorigenic Human Prostatic Epithelial Cell Line. Cancer Research. 61: 8135-8142, 2001.
J L Phillips, S W Hayward, Y Wang, J Vasselli, C Pavlovich, H Padilla-Nash, J R Pezullo, B M Ghadimi, G D Grossfeld, A Rivera, W M Linehan, G R Cunha, T Ried. The Consequences of Chromosomal Aneuploidy on Gene Expression Profiles in a Cell Line Model for Prostate Carcinogenesis. Cancer Research. 61: 8143-8149, 2001.
T Kurita, Y Z Wang, A A Donjacour, C Zhao, J P Lydon, B W O'Malley, J T Isaacs, R Dahiya, G R Cunha. Paracrine regulation of apoptosis by steroid hormones in the male and female reproductive system. Cell Death Differ. 2001 Feb;8(2):192-200.
Y. Z. Wang, S. W. Hayward, A. A. Donjacour, P. Young, T Jacks, J. Sage, R. Dahiya, R. Cardiff, M. Day, Gerald R. Cunha. Sex Hormone-induced Carcinogenesis in Rb-deficient Prostate Tissue. Cancer Research. 60: 6008-6017, 2000.
Wong YC, Wang YZ. Growth factors and epithelial-stromal interactions in prostate cancer development. International Review of Cytology. Jeon KW ed, Academic Press, 199: 65-116, 2000. [Abstract]
Y. Z. Wang and Y. C. Wong. Role of insulin-like growth factor-1 (IGF-1) and vascular endothelial growth factor (VEGF) in the development of prostate cancer in the Noble rat: Evidence for stromal-epithelial interactions. Prostate. 35: 165-17, 1998.