Drug Resistance Assay
The high take rate of subrenal capsule xenografts enables researchers to readily study tumor behavior (growth/progression/metastasis/acquired drug resistance) of a great variety of precancerous and cancerous diseases in vivo.
Many of our tumor tissue lines have known drug sensitivity/resistance for various cytotoxic drugs acquired from previous studies.
Status of drug-resistance markers in our tumor lines is known, or can be readily screened using tissue microarray or mRNA expression profiles.
Acquired drug resistance can also be established by treating tumor lines with multiple cycles and selecting drug-resistant subpopulations.
Lung cancer and ovarian cancer tumor lines show a variety of responses to standard chemotherapy.
Figure 1. Drug responses in ovarian Living Tumor Lines
Figure 2. Drug responses in lung Living Tumor Lines
T/C = average treated tumor mass/average control
Drug resistance lines are being developed via multiple
cycles of standard chemotherapy treatment of selected Living