Special Models

  • Based on their biological behavior in host, pathological grade and genotype of donor tumor, the Living Tumor Lines are divided into a number of characterized xenograft models. Each model can be subdivided according to their particular histopathological types.

 

Characterized cancer models at the Living Tumor Laboratory

Models

Tumor type

Low-grade cancer models
High-grade cancer models

Lung carcinoma, ovarian carcinoma, prostatic carcinoma, pancreatic carcinoma, renal carcinoma, sarcoma, lymphoma

Slow growing models
Fast growing models

Invasive models
Non-invasive models

Metastatic models
Non-metastatic models

Genomic/epigenetic Mutant/deletion models

Ovarian carcinoma (e.g. BRCA1 mutant), Lung carcinoma (e.g. ## fusion).

  • A number of paired sublines derived from cancer specimens from individual patients, but showing different biological behavior in host, are available. Such paired sublines provide unique models for studying specific mechanisms, discovering biomarkers and developing new targeted anticancer drugs.

 

Paired sublines developed in the Living Tumor Laboratory

Subline Type

Subline origin

Sublines

Bio-characteristics of sublines

Paired metastatic / non-metastatic tumor tissue sublines

Ovarian serous carcinoma

LTL-297A

No local tissue invasion, no metastasis in host

LTL-297B

Locally invasive, highly metastatic in host

Prostatic adenocarcinoma

LTL-64A

Metastasis to distant organs in host

LTL-64B

No metastasis in host

Prostatic adenocarcinoma

LTL-220A

Metastasis to distant organs in host

LTL-220B

No metastasis in host

Pancreatic adenocarcinoma

LTL-190A

 

LTL-190B

 

Paired androgen responsive / non-responsive tumor tissue sublines

Prostatic adenocarcinoma

LTL-64AR

Androgen-stimulated tumor growth

LTL-64AS

Androgen-suppressed tumor growth

LTL-64AI

Androgen-independent tumor growth

Paired fast growing / slow growing tumor tissue sublines

Ovarian serous carcinoma

LTL-247H

Fast growing with 5-6 days doubling time under the renal capsule

 

LTL-247S

Slow growing with 13 days doubling time under the renal capsule

 

Subline origin

Sublines

Bio-characteristics of sublines

LTL-79

LTL-79/C13

10 cycles of CDDP+VP16 treatment. Tumor is resistant to the drug

LTL-117

LTL-117/C6

6 cycles of CDDCP+VNB. Tumor is still response to the drug.

LTL-175

LTL-175/C6

6 cycles of carboplatin and paclitaxol treatment. Tumor is still response to the drug.

LTL-297B

LTL-297B/C4

4 cycles of carboplatin and paclitaxol treatment. Tumor is resistant to the drug.